Endocrine Abstracts

Turner syndrome (TS) is a chromosomal abnormality, due to a total or partial loss of one of the X chromosomes and is mostly characterized clinically by short stature and primary ovarian insufficiency. Spontaneous pregnancies in TS are rare (5%) and of relatively high risk, due to cardiovascular complications. Therefore, close medical monitoring is required. We report a case of a 21-year old woman with TS that had a full term uncomplicated pregnancy after spontaneous conception...

Introduction: Delayed diagnosis of a cardiovascular event is related with higher case-fatality rate in women as compared to men. In fact, accumulating evidence supports an association between the menopausal status and the development of cardiovascular disease (CVD). We aimed to assess the extent of subclinical vascular disorders in young, healthy postmenopausal women, with respect to the calculated cardiovascular risk.Methods: This cross-sectional study ...

Objectives: Glucocorticoids may affect cardiovascular risk. Polymorphisms in the glucocorticoid receptor (GlucR) gene have been associated with increased risk for cardiovascular disease. We investigated whether the common Bcl1 polymorphism of the GlucR gene (associated with increased sensitivity to glucocorticoids) may be associated with early markers of atherosclerosis.Methods: Two hundred and fourteen middle aged apparently healthy subjects (age &#8230...

Introduction-aim: It has been suggested that estrogen may play an important role in the regulation of endothelium-dependent vasodilatation in both sexes. Especially in men, estradiol administration has been shown to improve endothelial function; however such reports are conflicting. The aim of our study was to examine the relation of endogenous sex hormone levels with markers of early atherosclerosis in a cohort of apparently healthy individuals.Methods:...

Objective: Thyroid function tests (TFTs) have been associated with obesity; however associations with the type of adiposity have not been examined. Ultrasound (U/S) was used to assess regional adiposity in euthyroid individuals. Associations of thyroid function with obesity parameters and presence of the metabolic syndrome (MS) were investigated.Methods: Of 302 apparently healthy slightly overweight individuals (age 42.9±8.8, BMI 19.0–43.3, med...

Objective: Androgen may be detrimental for vascular health in women. Sensitivity to androgen is influenced by the CAG repeat length of the androgen receptor (AR) gene. We investigated possible associations between the CAG repeat polymorphism with the severity of CAD in women undergoing coronary angiography.Methods: We examined 131 postmenopausal women (45–88 years). CAD severity was assessed by the number of coronary vessels with >50% stenosis. ...

Objective: The association of SHBG levels with obesity, hyperinsulinemia and metabolic abnormalities is well recognized in both men and women. Recent data suggest that SHBG levels are an important predictor of cardiovascular disease (CVD) risk. Several methods have been used for the measurement of adiposity including ultrasonography (U/S) which is a reliable and low-cost method. We used U/S to assess regional adiposity and investigated possible associations with SHBG levels.</...

Objective: Androgen may be detrimental in the development of cardiovascular disease in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and thus the tissue androgen availability and early markers of atherosclerosis in apparently healthy women.Design and methods: In this prospective clinical study, 153 con...

Background: Subclinical Cushing’s syndrome (SCS) due to incidentally discovered adrenal adenomas (AI) has been associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance which are established risk factors for cardiovascular morbidity. Although functional and morphological (structural) changes of endothelium have been correlated with cardiovascular morbidity this has not been looked into detail in patients with adrenal incidentalomas....

Background: The menopausal transition has been associated with a heightened risk of cardiometabolic complications, including new onset diabetes mellitus (NODM). Statin-use increases the NODM-risk in the general population, however, their impact on NODM-risk specifically in postmenopausal populations has not been adequately studied.Objectives: To estimate the effect of statin-use at baseline on the risk of NODM in postmenopausal women.<p class="abstex...